EnzymeRSI: A dual-loop recursive self-improvement system for enzyme design
EnzymeRSI is a dual-loop recursive self-improvement system that evolves harness assets and algorithms without changing model weights, closing the loop with a cloud laboratory. It improved ProteinGym Spearman correlations by 0.044 on average, reached a PCC of 0.849 on ThermoMPNN, and demonstrated wet-lab success including a 31.1-fold catalytic efficiency increase in KOD-E polymerase. The system offers a new paradigm for autonomous enzyme engineering by treating workflow and algorithm development as a single falsifiable dry-to-wet loop.
Why it matters: This paper presents a concrete, recent AI system with measurable improvements in both computational benchmarks and prospective wet-lab validations, offering significant value for readers interested in autonomous scientific discovery and enzyme engineering.