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GPT-6-Astra solves 49 of 50 physics problems on TheoPhysEval benchmark

On the TheoPhysEval benchmark, GPT-6-Astra reportedly solved 49 of 50 unpublished theoretical physics calculations as accurately as leading specialists, according to The Decoder. Researchers noted that some apparent failures were actually errors in the experts' own reference solutions. They also said physics has not seen a breakthrough comparable to those in mathematics because the agents lack "taste." They expect autonomous, top-level AI research could arrive soon, with consequences for how you

The Decoder3d agoScore 70
GPT-6-AstraTheoPhysEvalAI for science
Research Editor selected

Microsoft Research Open-Sources RetroChimera, an Ensemble Model for Retrosynthesis Prediction

Microsoft Research describes RetroChimera, a retrosynthesis framework published in Nature that ensembles a Transformer-based de-novo model (R-SMILES 2) with a graph neural network that selects reaction templates (NeuralLoc). A learned re-ranking strategy combines their complementary strengths, improving recall of rare reactions and alignment with expert chemists' preferences. In expert assessments, RetroChimera was accepted on nine of ten challenging targets versus fewer for baselines, and in bl

Why it matters: It gives chemists and AI researchers an openly available ensemble retrosynthesis model with published validation, potentially accelerating molecule synthesis planning.

Microsoft ResearchSep 21, 2026Score 83
Microsoft Researchretrosynthesissmall molecule synthesis