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Audit Finds LLM Health Advice Varies by User Persona, Factual Floor Helps but Not Uniformly

A new arXiv study audits six LLMs from four providers on smoking-cessation advice, finding that responses vary significantly based on user persona. Models mention FDA-approved cessation medications less often to teen personas (by 32–67 percentage points) and often give fewer facts to users claiming healthcare expertise. A system prompt enforcing a factual floor reduced persona differences in all models, but its effect on overall fact coverage varied across models, indicating limited transferability. The authors release all 2,880 responses and analysis code.

AI Brief

This study provides concrete, recent evidence of persona-dependent variation in LLM health advice and tests a practical intervention, offering actionable insights for AI deployment in high-stakes domains.

arXiv:2610.42039v1 Announce Type: new Abstract: Hundreds of millions of people now ask large language model (LLM) chatbots for health advice, which raises a question that is simple to pose and hard to answer: does everyone get the same advice? We audit six widely deployed LLMs from four providers on smoking cessation, a domain with codified clini- cal guidance and substantial public-health stakes, by putting the same four cessation questions to twelve user personas that differ in life stage, self-described expertise, and smoking history, for a total of 2,880 responses. What the models say depends on who appears to be asking. Every model named FDA-approved prescription cessation medications less often to teen personas than to adult personas, by 32 to 67 percentage points, and in five of six models a persona presenting health- care expertise received fewer facts than a persona presenting none. We then evaluate one deployable intervention: a short system prompt specifying a factual floor, the set of core med- ical facts every user should receive when they are relevant, while leaving tone, vocabulary, and framing free to adapt. The prompt narrows persona differences in every model, but its effect on overall fact coverage varies in both magnitude and direction across models, so a prompt validated on one system cannot be assumed to transfer to another. Two cautions frame these results. Equal mention rates are not always the correct clinical target, because prescription cessation pharmacother- apy is not recommended for minors, so a defensible factual floor must be age-aware rather than uniform. And because our personas vary on several attributes at once, we report scenario- level differences rather than isolated effects of age or expertise. We release all 2,880 responses and the analysis code.
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