Research
RIVER: Evidence-guided multi-agent retrieval for enzyme–reaction discovery
RIVER is a multi-agent framework that coordinates LLMs, biochemical tools, and knowledge resources to perform bidirectional enzyme–reaction retrieval. It assembles multi-level evidence and uses validation modules to rerank candidates, achieving top success rates on public benchmarks and outperforming general-purpose and biology-specialized multi-agent systems in E. coli retrieval tasks.
enzyme function annotationmulti-agent systemsretrieval